Emisphere Technologies, Inc.

Monica Leipold

Andrea Leone-Bay

Sam J Milstein

Donald J Sarubbi

David Gschneidner

Doris C O'Toole

John Smart

Elizabeth Flanders

The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.

Pulmonary delivery of active agents

The present invention relates to pulmonary delivery of active agents. Acylated or sufonated amino acids are used as carriers to facilitate pulmonary delivery of active agents to a target.

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Thornwood, NY, United States of America

Monica Leipold