Cornell University

Bioventures, LLC

University of Arkansas

Sloan-kettering Institute for Cancer Research

Universidad Tecnica Particular De Loja

New York Botanical Garden

Monica L Guzman

Cesar M Compadre

Darin E Jones

Paola E Ordonez

Peter Anthony Crooks

Gabriela Chiosis

Tony Taldone

Omar Malagon

Mary L Alpaugh

Erica M Gomes-Dagama

Mariano Martinez

Michael J Balick

Flavio G Gaudio

Hongliang Zong

Giovanni Vidari

The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.

Dehydroleucodine derivatives and uses thereof

The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.

Hetero-substituted cyclic lactone analogues and uses thereof

The disclosure provides evidence that the abundance of this particular 'oncogenic HSP90' species, which is not dictated by HSP90 expression alone, predicts for sensitivity to HSP90 inhibition therapy, and thus is a biomarker for HSP90 therapy. The disclosure also provides evidence that identifying and measuring the abundance of this oncogenic HSP90 species in tumors predicts of response to HSP90 therapy. 'Oncogenic HSP90' is defined herein as the HSP90 fraction that represents a cell stress specific form of chaperone complex, that is expanded and constitutively maintained in the tumor cell context, and that may execute functions necessary to maintain the malignant phenotype. Such roles are not only to regulate the folding of overexpressed (i.e. HER2), mutated (i.e. mB-Raf) or chimeric proteins (i.e. Bcr-Abl), but also to facilitate scaffolding and complex formation of molecules involved in aberrantly activated signaling complexes (i.e. STATS, BCL6).

Uses of labeled HSP90 inhibitors

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Ithaca, NY, United States of America

Monica L Guzman