Glaxo Group Limited

Monica Cacho-Izquierdo

David Barros-Aguirre

Carlos Alemparte-Gallardo

Jose Maria Fiandor Roman

Neil David Pearson

Alan Joseph Hennessy

Jose Luis Lavandera Diaz

Modesto Jesus Remuinan-Blanco

Modesto Jesús Remuiñan-Blanco

Christopher Barfoot

Compounds of Formula (I), wherein substituents R, Rand Rare as defined, and Ar represents substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, furanyl, imidazolyl and thiophenyl substituted by a hydroxyalkyl substituent and an optional other substituent; compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

Naphthyridin-2 (1 H)-one compounds useful as antibacterials

Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof: (relative chemistry shown) pharmaceutical compositions comprising them, their use in therapy especially against tuberculosis, and methods of preparing them are described.

Compounds

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Research Triangle Park, NC, United States of America

Monica Cacho-Izquierdo