The Brigham and Women's Hospital, Inc.

Case Western Reserve University

Monica Bertagnolli

Sanford D Markowitz

Richard S Blumberg

Robert George Edward Holgate

Susan Dana Jones

Yu-Hwa Huang

Amit Gandhi

Charles Yoon

Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Humanized and affinity-matured anti-CEACAM1 antibodies

The disclosure provides, among other things, a method of decreasing resistance to the chemopreventive properties of non-steroidal anti-inflammatory agents, e.g., celecoxib, particularly in the prevention of cancer, e.g., colon cancer, by increasing the levels or activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The disclosure also provides a method of identifying compounds that upregulate or reactivate 15-PGDH. The disclosure also provides a method of identifying an individual suitable for treatment with a non-steroidal anti-inflammatory agent in the treatment or prevention of colon cancer.

15-PGDH in colon cancer

Growing community of inventors

Newton, MA, United States of America

Monica Bertagnolli