Medichem, S.a.

Corporacion Medichem, S.l.

Monica Benito Velez

Ernesto Duran Lopez

Jordi Bosch I Lladó

Stephen Benedict David Winter

Ernest Duran Lopez

The invention relates to solid forms of the anti-epileptic agent lacosamide (I). The invention also relates to mixtures of solid forms of lacosamide. The invention further relates to mixtures of lacosamide enantiomers crystallized in a conglomerate Form and the use thereof in providing enantiomerically enriched lacosamide, preferably lacosamide enriched with the (R)-enantiomer of lacosamide. 

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This invention provides a novel dicarboxylic acid salt forms of varenicline, namely varenicline fumarate, and methods for making same. Varenicline salts are useful for treating smoking addition. In one embodiment of the instant invention, the varenicline fumarate shows an XRD pattern (2&#x3b8;)) (&#xb1;0.2&#xb0; having characteristic peaks at 10.6, 11.9, 13.2, 16.2, 16.6, 18.0, 21.5, 22.6, 25.7, 28.5 and 29.1&#xb0;. In another embodiment, the varenicline fumarate is prepared by (i) contacting varenicline with fumaric acid, optionally in the presence of a suitable solvent, and removing the solvent when necessary, or (ii) contacting varenicline fumarate salt with a suitable solvent, and removing the solvent.

Fumaric acid salt of varenicline

This invention provides a novel crystalline sitagliptin ethanedisulfonate salt having the structure set forth below, and a method for using same to treat type 2 diabetes. 

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Barcelona, Spain

Monica Benito Velez