Dexcom, Inc.

Monica A Rixman

Robert James Boock

Peter C Simpson

Michael J Estes

Huashi Zhang

Kristina Lawrence

Mark C Brister

Kum Ming Woo

Melissa A Nicholas

James H Brauker

James R Petisce

Jack Pryor

Mark Allan Tapsak

Matthew D Wightlin

Dubravka Markovic

Lisa Nguyen

Seth R Brunner

Arthur Chee

Apurv Ullas Kamath

Paul V Goode, Jr

John Burd

Rathburn K Rhodes

Victoria E Carr-Brendel

Mark C Shults

Rathbun K Rhodes

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Polymer membranes for continuous analyte sensors

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

Analyte sensor

Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.

Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

Silicone based membranes for use in implantable glucose sensors

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Medford, MA, United States of America

Monica A Rixman