Vysis, Inc.

Other

Amoco Corporation

Mona S Legator

Larry E Morrison

Michael L Bittner

Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.

Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization

Direct label probe compositions which counterstain genomic DNA are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the total genomic DNA of a multi-chromosomal organism, especially man, and the segment mixture is approximately representative of such total genomic DNA. These probe compositions can be used concurrently or sequentially with other probe compositions. Instead of intercalating with DNA as in prior art chemical counterstains, these probe compositions hybridize with complementary segments that are present in the genomic DNA of a specimen.

Methods for genome identification using direct label probe composition

Methods for detection by in situ hybridization of multiple chromosomes

Probe compositions for chromosome identification and methods

Direct label transaminated DNA probe compositions for chromosome

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Chicago, IL, United States of America

Mona S Legator