Lcb Pharma Inc.

Université D'ottawa

Mona Nemer

Yvan Guindon

Philippe Mochirian

Michel Prévost

The compounds are nucleoside and nucleotide analogues that can be used as anticancer or antiviral agents. The compounds include tetrahydrofuranyl or tetrahydrothienyl moieties with quaternary stereogenic all-carbon center at the 3' position and bear a phosphoryl group at either one of, or both of positions C5&#x2032; and/or C3&#x2032;; have a quaternary stereogenic all-carbon center at one of the 3&#x2032; position, 2&#x2032; position, or no quaternary stereogenic center at all, and bear a &#x3b2;-blocked lipoate derivative attached through an amide bond to the primary amine of the nucleobase; or have a quaternary stereogenic all-carbon center at the 2&#x2032; position and bear a phosphorylated prodrug at the C5&#x2032;-position and a &#x3b2;-blocked lipoate derivative attached through an amide bond to the primary amine of the nucleobase 

Nucleoside analogues and methods of use thereof

The compounds are nucleoside and nucleotide analogues that can be used as cardioprotective agents. The compounds include tetrahydrofuranyl or tetrahydrothienyl moieties with quaternary stereogenic all-carbon centers at the 2' position and a phosphonate ester at C5&#x2032; position. 

Nucleoside and nucleotide analogues bearing a quaternary all-carbon stereogenic center at the 2' position and methods of use as a cardioprotective agent

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Ottawa, Canada

Mona Nemer