Tecan Trading Ag

Fisher Scientific Company

Mona D Jensen

Gregory John Kellogg

Stephen G Kieffer-Higgins

Shari Ommert

Mikayla Kob

Brian B Lentrichia

Kwok K Yeung

Robert J Dummel

Andrea Pierce

Pih-Kuei C Huang

Keith Morneau

Hsin Chiang Lin

This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays.

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays

A sample is mixed with a reagent containing stably suspended particles coated with a binding pair member complementary to or competitive with the target binding pair member. A centrifugal force applied during reaction is sufficient to change the concentration of particles at a locus relative to overall particle concentration. Light transmission or scattering is measured kinetically at the locus, especially in a microcentrifugal analyzer.

Centrifugal kinetic agglutination assay

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Hampstead, NH, United States of America

Mona D Jensen