Other

Covidien LP

Imperial Innovations Limited

Sparta Biodiscovery Limited

Imperial College Innovations Limited

Molly Stevens

George B Hanna

Shobhit Arya

Lei Su

Daniel S Elson

Vadzim Chalau

Kristy Lee Cloyd

Martin A B Hedegaard

Charlotte Katherine Williams

Rein Ulijn

Jelle Penders

Isaac Pence

Morgan Mager

Erik Daniel Aili

Liling Koh

Seth Dylan McCullen

Helen Autefage

Min Tang

Anna Sague Laromaine

Martin AB Hedegaard

An automated method of particle analysis is performed using an electromagnetic radiation source for generating a beam of electromagnetic radiation, a focusing element for directing the beam to a particle capture zone, a detector configured to detect a signal response from the particle capture zone and a control system. An electromagnetic radiation beam is focused onto a particle-conveying medium to define the particle capture zone for capturing a candidate particle within the beam. A first data acquisition procedure is performed to test for particle capture. If particle capture is not detected, the first data acquisition procedure is repeated. If a particle capture is detected within the beam, a second data acquisition procedure is performed to capture particle data using at least one analysis modality, following which the optical beam intensity is reduced to a sub-capture level to release the particle from the particle capture zone. The steps are repeated for successive particles in the particle-conveying medium.

Single particle automated Raman trapping analysis

A medical instrument is provided and includes a housing and a shaft coupled to the housing. The shaft has a proximal end and a distal end. An end-effector assembly is disposed at the distal end of the shaft. The end-effector assembly includes first and second jaw members. At least one of the first and second jaw members is movable from a first position wherein the first and second jaw members are disposed in spaced relation relative to one another to at least a second position closer to one another wherein the first and second jaw members cooperate to grasp tissue therebetween. The medical instrument also includes one or more light-emitting elements and one or more light-detecting elements configured to generate one or more signals indicative of tissue florescence. The one or more light-emitting elements are adapted to deliver light energy to tissue grasped between the first and second jaw members.

Surgical device with an end-effector assembly and system for monitoring of tissue during a surgical procedure

The present invention relates to compositions, assay devices, kits and methods for detecting the presence, amount and/or activity of an analyte in a sample. In particular, the present invention relates to the detection of enzymes. The present invention also relates to methods of diagnosing diseases associated with dysregulation of enzymes, screening for modulators of enzymatic activity, candidate antimicrobial peptides and toxins.

Assay for analytes based on aggregation

The present invention relates to a layered fibrous construct for use as a scaffold for repairing or replacing cartilage or cartilage-like tissue, and a process for the production thereof.

Layered fibrous construct

The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources.

Carbohydrate lactone polymers

The present invention provides a particle aggregate comprising particles linked to other particles via linkers that are capable of being cleaved by an enzyme. The particles may be linked directly to other particles by the linkers or may be linked indirectly by means of a binding moiety. The invention also provides a particle coupled to a binding moiety via a linker that can be cleaved by an enzyme. The present invention may be used in diagnosing a disease or condition associated with the enzyme, or may be used to treat such a disease or condition whereby the drug is retained in the particle aggregate until the linkers are cleaved by the enzyme.

Particles

Growing community of inventors

London, United Kingdom

Molly Stevens