Flagship Pioneering Innovations V, Inc.

Dsm Nutritional Products Inc.

Flagship Pioneering Innovations Vii, LLC

Molly Krisann Gibson

Geoffrey Von Maltzahn

Jacob Rosenblum Rubens

John Miles Milwid

Christopher Matthew Liu

Nathan Wilson Stebbins

Neal Gordon

Michael Travis Mee

Bo Zhang

Kyle Marvin Trudeau

Kiana Mahdaviani

Ruth Thieroff-ekerdt

Camilo Ayala Breton

Alexandra Rachael Sneider

Brigham Jay Hartley

Tamar Rose Putiri

Matthew Milnes Dobbin

Benjamin Andrew Portney

Narahari Subbanna Pujar

Han Yuan

Neal Francis Gordon

Geoffrey A Von Maltzahn

Ruth Thieroff-Ekerdt

The disclosure provides, for example, single stranded, covalently closed DNA that does not form a double stranded structure longer than 100 base pairs. The ssDNA may encode an effector sequence, for instance a therapeutic protein. The ssDNA may comprise a nuclear targeting sequence (NTS). In some embodiments, the ssDNA shows decreased activation of the innate immune system compared to an otherwise similar dsDNA.

DNA compositions and related methods

Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.

Glucose glycans for treating urea cycle disorders

In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Compositions for facilitating membrane fusion and uses thereof

Growing community of inventors

Medford, MA, United States of America

Molly Krisann Gibson