Synphar Laboratories, Inc.

Taiho Pharmaceutical Company Limited

Synphar Laboratories, Ind.

Mohsen Daneshtalab

Ronald G Micetich

Dai Q Nguyen

Chan M Ha

Inderjit Sidhu

Hiep T Luu

Norio Unemi

Jehangir Khan

Ronald J Micetich

Mark Abel

Yadagiri Bathini

Tetsuo Furukawa

Laurence M Tempest

Kazuharu Noguchi

Sameeh Salama

A compound of formula I, or an optical isomer or pharmaceutically acceptable salt thereof, ##STR1## is disclosed as well as a pharmaceutical composition and a method of treating or preventing a fungal infection using the compound.

Triazoles as therapeutic agents for fungal infections

A process for the synthesis of compounds of the formulas Ia and Ib below, wherein R.sub.1, R.sub.2, and R.sub.3, which are the same or different, are each selected from hydrogen and C.sub.1 -C.sub.4 alkyl, including the compound Anabaseine (Ia, wherein R.sub.1 =R.sub.2 R.sub.3 =H) (3,4,5,6-tetrahydro-2', 3'-bipyridine), the process comprising reacting sodium salt of .delta.-valerolactone with substituted ethyl nicotinate derivative to produce the Claisen product sodium 3-nicotinoyl-2-tetrahydropyranone enolate derivative, heating the sodium 3-nicotinoyl-2-tetrahydropyranone enolate derivative with concentrated HCl to produce 3-(5-chloro-1-pentanone-1-yl) pyridine derivative, dissolving the 3-(5-chloro-1-pentanone-1-yl) pyridine derivative in ethanol and then heating the 3-(5-chloro-1-pentanone-1-yl) pyridine derivative in ethanol with ethanolic ammonia solution in a sealed container to produce the compound Ia. Also, the process steps in the above process, and the products and intermediate products produced thereby. ##STR1##

Synthesis of anabaseine, salts and derivatives thereof

A 6.beta.-substituted penicillanic acid of the formula XII: ##STR1## or a pharmaceutically acceptable salt or ester thereof, wherein

6.beta.-substituted penicillanic acids as beta-lactamase inhibitors

A 1,4-dihydropyridine derivative of the formula I: ##STR1## is provided in which: A is an azole moiety;

Generation of 1,4-dihydropyridine derivatives

There are provided compounds having the general formulae ##STR1## wherein R is a non-fused azole moiety;

Novel generation of heteroaryl thio, sulfoxy, or sulfonyl alkyl azoles

A heteroaryloxyalkylheterocyclic derivative of the Formula I:

Novel generation of heteroaryloxyalkyl heterocycles with

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Edmonton, Canada

Mohsen Daneshtalab