Medtronic Minimed, Inc.

Medtronic, Inc.

Covidien LP

Mohsen Askarinya

David Probst

Randal C Schulhauser

Patrick W Kinzie

Akhil Srinivasan

Mark R Boone

Santhisagar Vaddiraju

Daniel Hahn

Lejun Wang

Melissa Tsang

Chi-En Lin

Andreas A Fenner

James Kevin Carney

Mark D Breyen

Thomas P Miltich

Michael E Miller

Colin A Chong

Robert C Mucic

Richard L Brown

Larry Earl Tyler

Steven C Jacks

Rajiv Shah

David A Ruben

Bradley Chi Liang

John Wainwright

Sarnath Chattaraj

Richard J O'Brien

Jennifer Lorenz Marckmann

Erik J Herrmann

Mark S Ricotta

Alejo Chavez Gaxiola

Peter Ajemba

Tyler S Stevenson

Jeff M Cherry

Tyler R Wong

Xin Heng

Kenneth Heames

Nathan Hobbs

Anirban Chakraborty

Poonam S Gulati

Randolph E Crutchfield

Charles R Gordon

Guangping Zhang

Brian T Kannard

John K Day

Ashwin K Rao

Kenneth W Cooper

Kris R Holtzclaw

Quyen Ong

Aaron Gilletti

Christina Pai

Brian P McGee

Mary Ellen B Coe

Cynthia J Jones

Hsiu-Hsin Chung

Jorge L Nieto

Robert Mckinlay

John V Anderson, Ii

Inthirai Somasuntharam

Michael N Missaghi

Brennan Toshner

Vu Nguyen

Parisa Kamgar

Tina F Abnoosi

Ariel Reider

Carlos E Maldonado

Riley Clayton Kimball

Wally Dong

Mark Phelps

Mark A Boone

Larry E Tyler

Medical devices and related systems and methods are provided. A method of controlling medication delivery based on sensor input involves obtaining a measurement parameter representing an electrical response of a first instance of a sensing element to a physiological condition of a person. The measurement parameter is converted into a calibrated measurement parameter using calibration data specific to the first instance of the sensing element. The method further involves determining a measurement value using the calibrated measurement parameter as input to a performance model. The performance model is derived from historical calibrated measurement parameters and corresponding reference values. The historical calibrated measurement parameters are from other instances of the sensing element. A command is then determined based on the measurement value and sent to a medical device. The command causes the medical device to deliver a dose of medication influencing the physiological condition of the person.

Medication delivery using calibrated sensor measurements

The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

Sensors for 3-hydroxybutyrate detection

A method of testing one or more analyte sensors each comprising a first electrode; a second electrode; and a material layer disposed on or above the first electrode; the method including (a) applying a voltage potential to the first electrode with respect to the second electrode; (b) measuring a test signal comprising an output current from the first electrode that results from the application of the voltage potential; (c) using the test signal from (b) to observe an electrical characteristic of the analyte sensor; and (d) correlating the electrical characteristic a parameter associated with an electrochemical response of the analyte sensor to an analyte, wherein the testing is under dry conditions without exposure of the electrodes to a fluid containing the analyte or an in-vivo environment containing the analyte.

Dry electrochemical impedance spectroscopy metrology for conductive chemical layers

A sensor having a distal end and an intermediate region adjacent to the distal end is provided. The sensor includes an insulator base substrate, sensor electrodes over the insulator base substrate, an electrode lead pattern over the insulator base substrate, wherein the electrode lead pattern includes electrode leads configured for contact with the sensor electrodes, and wherein the electrode leads extend completely across the intermediate region in a longitudinal direction, and a structural backing layer over the electrode lead pattern and insulator base substrate; wherein a side edge of the structural backing layer over the electrode lead pattern extends completely across the structural backing layer in the longitudinal direction.

Structurally reinforced sensor and method for manufacturing the same

An embodiment of a sensor device includes a base substrate, a circuit pattern formed overlying the interior surface of the substrate, a physiological characteristic sensor element on the exterior surface of the substrate, conductive plug elements located in vias formed through the substrate, each conductive plug element having one end coupled to a sensor electrode, and having another end coupled to the circuit pattern, a multilayer component stack carried on the substrate and connected to the circuit pattern, the stack including features and components to provide processing and wireless communication functionality for sensor data obtained in association with operation of the sensor device, and an enclosure structure coupled to the substrate to enclose the interior surface of the substrate, the circuit pattern, and the stack.

Waferscale physiological characteristic sensor package with integrated wireless transmitter

A biocompatible medical device may include an electrochemical sensor including a common reference electrode; at least one counter electrode; and a work electrode platform comprising a plurality of respective work electrodes, each respective work electrode electrically coupled to the common reference electrode and comprising a respective reagent substrate configured to react with a respective analyte to produce a respective signal indicative of a concentration of the respective analyte; and processing circuitry operatively coupled to the electrochemical sensor, and configured to receive from the electrochemical sensor a plurality of signals from the plurality of respective work electrodes; identify the respective signal corresponding to a respective selected work electrode; and process the identified signal to determine the concentration of the respective analyte associated with the respective selected work electrode.

Electrochemical sensor including multiple work electrodes and common reference electrode

The present disclosure provides methods and techniques associated with a planar transformer for an apparatus. The planar transformers include a substrate carrying electronic components and a continuous core that is formed by distributing the encapsulant material uniformly around the substrate unit to define a consistent cross-sectional area for the magnetic path. The electronic components include primary windings and secondary windings associated with the transformer. In some embodiments, the encapsulant material is molded to seals air gaps to the substrate unit.

Method of forming a transformer assembly

Medical devices and related systems and methods are provided. A method of calibrating an instance of a sensing element involves obtaining fabrication process measurement data from a substrate having the instance of the sensing element fabricated thereon, obtaining a calibration model associated with the sensing element, determining calibration data associated with the instance of the sensing element for converting the electrical signals into a calibrated measurement parameter based on the fabrication process measurement data using the calibration model, and storing the calibration data in a data storage element associated with the instance of the sensing element.

Sensor calibration using fabrication measurements

Sensors and methods for manufacturing sensors are provided. An exemplary method for manufacturing a sensor includes forming an electrode lead pattern over an insulator base substrate. Further, the method includes forming a structural backing layer over the electrode lead pattern and insulator base substrate. Also, the method includes performing a cutting process to cut through the structural backing layer to form a structural backing over the electrode lead pattern.

The invention includes method and materials designed to measure the material properties (e.g. thickness) of layers of material in a sensor using non-Faradaic EIS (Electrochemical Impedance Spectroscopy) methods. The methods are non-destructive, very sensitive and rapid. Typically in these methods, an AC voltage is applied to the desired material layer while the output current and therefore impedance is measured. This voltage can be applied in multiple frequencies in sweep mode in order to detect both the material and, for example, the thickness of the target material. In this way, EIS allows the characterization of properties of various layers of material disposed in devices such as electrochemical glucose sensors.

Measurement of device materials using non-Faradaic electrochemical impedance spectroscopy

A multi-chip modular wafer level package of a high voltage unit for an implantable cardiac defibrillator includes one or more high voltage (HV) component chips encapsulated with other components thereof in a polymer mold compound of a single reconstituted wafer, wherein all interconnect segments are preferably located on a single side of the wafer. To electrically couple a contact surface of each HV chip, located on a side of the chip opposite the interconnect side of the wafer, the reconstituted wafer may include conductive through polymer vias; alternately, either wire bonds or layers of conductive polymer are formed to couple the aforementioned contact surface to the corresponding interconnect, prior to encapsulation of the HV chips. In some cases one or more of the components encapsulated in the reconstituted wafer of the package are reconstituted chips.

Wafer level packages of high voltage units for implantable medical devices

An electrochemical sensor may include a common reference electrode, at least one counter electrode, and a work electrode platform including a plurality of respective work electrodes. Each respective work electrode of the plurality of respective work electrodes may be electrically coupled to the common reference electrode and include a respective reagent substrate configured to react with a respective analyte to produce a signal indicative of a concentration of the respective analyte.

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Chandler, AZ, United States of America

Mohsen Askarinya