King Abdulaziz University

Mohmmad Younus Wani

Irfan Ahmad Rather

Usman Saeed

Hesham Alhumade

Sami-ullah Rather

Yan Yan Hor

Yong Ha Park

Aqeel Ahmad Taimoor

Hisham S Bamufleh

Khalid Rehman Hakeem

Majid Rasool Kamli

Walid M Alalayah

Jamal S M Sabir

Ahmad Firoz

Provided herein are ionic liquids that can be used as antifungal agents alone or in combination with Amphotericin B. Also disclosed are methods of synthesis of the ionic liquids and inhibiting fungal growth and methods of treating fungal infections using the disclosed compounds. The disclosure provides antifungal agents that potentiate the antifungal activity of Amphotericin B, a commonly used antifungal drug that could be used alone or in combination. This combination will help control and combat the infections caused by drug resistantin immunocompromised patients.

Antifungal ionic liquid and Amphotericin B combination

Provided herein are homoleptic metal coordination complexes that induce cellular apoptosis and cell cycle arrest in G0/G1 phase in fungus, such asspp. Also disclosed are methods of inhibiting fungal growth and methods of treating fungal infections using the disclosed compounds. The disclosed compounds exhibit anti-activity against fluconazole resistant and sensitive strains ofat low concentrations.

Homoleptic metal coordination complexes as antifungal agents

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Jeddah, Saudi Arabia

Mohmmad Younus Wani