Imaginative Research Associates, Inc.

Chesebrough-pond's Inc.

Chesebrough-pond's USA Co., Division of Conopco, Inc.

Medicis Pharmaceutical Corporation

Mohan Vishnupad

Jose E Ramirez

Eugene H Gans

Bhiku G Patel

Kuljit S Bhatia

William Howard Schmitt

Thomas M Deppert

Robert Alan Bornfriend

Robert J Tanko

The present invention is a delivery system comprising a pad and a liquid composition, comprising an insoluble dermatologically active ingredient with a viscosity that permits substantially uniform absorption of the composition onto the pad, and the pad is in then packaged in a sealed container.

Delivery system for topical medications

Compositions for topical application for treating a skin disorder (e.g., acne) include a retinoid, which is solubilized completely in alcohol only with the aid of cosolvents such as esters (e.g., alkyl benzoate, isopropyl palmitate, isopropyl myristate, diisopropyl adipate and their derivatives). This completely solubilized retinoid can be used to formulate an emulsion system or liquid to powder suspension containing a second active, such as an antibiotic (e.g., clindamycin).

Retinoid solutions and formulations made therefrom

Two separate compositions, one containing an effective anti-acne treating amount of a first active ingredient and one containing a second active ingredient that is incompatible with the first active ingredient are packaged within and dispensed from a common dispenser. By packaging these two active ingredients in this manner, long shelflife and convenient dispensing and application are provided.

Antibiotic/benzoyl peroxide dispenser

Substantially anhydrous compositions having a viscosity greater than 1000 centipoise are prepared by combining a polar solvent with a thickening agent selected from the group consisting of acrylic acid polymers and polyacrylamides. These compositions are particularly suited for topical use to deliver beneficial agents to the skin of a user. Being anhydrous, the compositions are particularly well suited to effectuate the delivery of beneficial agents that are unstable over time in aqueous systems.

Anhydrous creams, lotions and gels

Two separate compositions, one containing an antibiotic and one containing benzoyl peroxide are packaged within and dispensed from a common dispenser. More particularly, a dual dispenser contains i) a first composition that is substantially anhydrous and includes a polar solvent, an antibiotic and a thickening agent selected from the group consisting of acrylic acid polymers and polyacrylamides; and ii) a second composition containing benzoyl peroxide or, alternatively, a retinoid. By packaging these two anti-acne active ingredients in this manner, long shelflife and convenient dispensing and application are provided.

Cleansing bars are formed from compositions containing a liquid phase, particulate silica and a cleansing agent. The particulate silica is present in an amount to provide sufficient hardness to the composition to facilitate processing into a bar while maintaining good foaming despite a high liquid content.

Cleansing bar with high levels of liquid and particulate silica

Novel clear solutions or gels containing a volatile hydrocarbon, surfactants and a coupling agent do not separate, but rather due to solubilization of the volatile hydrocarbon by the coupling agent, provide acceptable consumer products.

Instant lathering clear solutions and gels

Novel clear solutions or gels containing a volatile hydrocarbon, surfactants and a polyalkylene oxide block copolymer coupling agent do not separate, but rather due to solubilization of the volatile hydrocarbon by the coupling agent, provide acceptable consumer products.

Post foaming clear gels and solutions

Cleansing bars are formed from compositions containing an oil phase, particulate silica and a cleansing agent. The particulate silica is present in an amount to provide sufficient hardness to the composition to facilitate processing into a bar while maintaining good foaming despite a high oil content.

Cleansing bar with high levels of emollients and particulate silica

Non-irritating compositions containing benzoyl peroxide and a non-irritating benzoic acid ester are useful in preparing products suitable for use in contact with the skin.

Benzoyl peroxide and benzoate ester containing compositions suitable for

Cosmetically elegant anhydrous foaming creams contain high levels of glycerin and emollients, sodium cocoyl isethionate at levels of 19% or less and an effective amount of a detergent additive to increase the softness of the composition. The detergent additive is preferably one of the following: sodium lauryl sulfate, a sodium salt of fatty acid taurate, an acyl glutamate, an .alpha.-olefin sulfonate or a neutralized lauryl phosphoric acid. The detergent additive can be present in an amount from about 1 to about 20 weight percent.

Anhydrous foaming composition containing low concentrations of

Compositions containing potassium polymetaphosphate and a solubilizing agent are used to increase the viscosity of water and thereby improve the delivery and function of personal care, household and pharmaceutical products.

Compositions containing kurroll's salt

Cosmetically elegant creams contain high levels of glycerine and emollients, sodium cocoyl isethionate at levels of 19% or less and sodium lauryl sulfate at a level of 1 to 5 percent.

The present invention relates to liquid, lotion-like aqueous oil-in-water dispersion compositons including emulsions containing large amounts of oil or oil/wax mixtures, a volatile organic foam-producing liquid, alone or in combination with foam suppressing agents, if necessary, to and surface active agent or agents which increase the solubility of the foam-producing liquid in the oil or oil/wax mixture. The present compositions are dispersions including mixtures which do not foam or self-dispense from a non-pressurized container at temperatures from RT to 120.degree. F., then can be poured onto a wet surface at room temperatures and spread to form a thin cleansing coating which will foam under ambient conditions to leave a residue of the oil or oil/wax mixture for cosmetic, medicinal, aesthetic, protection or other purposes.

Self-foaming oil compositions and process for making and using same

Cross-linked aqueous dispersions and emulsions and method for producing casts of any desirable shape therefrom the dispersions comprising a water dissipatable polymer in an amount from 18 to 30 percent by weight based on the total weight of the composition; water in an amount from 67 to 30 percent by weight based on the total weight of the composition; a source of multivalent metallic ions in an amount of 0.1 to 5 percent by weight based on the total weight of the composition; and humectant in an amount from 0.1 to 40 percent by weight based on the total weight of the composition and the emulsions comprising a water dissipatable polymer in an amount from 18 to 30 percent by weight based on the total weight of the composition; water in an amount from 67 to 80 percent by weight based on the total weight of the composition; emollient oils in an amount from 0.1 to 25 percent by weight based on the total weight of the composition; a source of multivalent metallic ions in an amount from 0.1 to 5 percent by weight based on the total weight of the composition; humectants in an amount from 0.1 to 40 percent by weight based on the total weight of the composition; and emulsifier in an amount from 0.01 to 5 percent by weight based on the total weight of the composition.

Growing community of inventors

Monroe, CT, United States of America

Mohan Vishnupad