The University of Melbourne

Immulogic Pharmaceutical Corporation

Immulogic Pharmaceuticals, Inc.

Immulogic Pharamaceutical Corp.

Mohan Bir Singh

Robert Bruce Knox

Penelope Smith

Asil Avjioglu

Terryn Hough

Piyada Theerakulpisut

Eng Kok Ong

Cenk Suphioglu

Huiling Xu

Ines Swoboda

Nicole Deweerd

Prem L Bhalla

The present invention relates generally to reagents useful in the immunotherapeutic or immunoprophylactic treatment of allergic diseases. More particularly, the present invention provides modified allergens exhibiting reduced IgE interactivity including reduced IgE production-stimulatory activity, while retaining T-cell antigenicity, which are useful in the immunomodulation of type I allergic disease conditions. The present invention further contemplates a method of immunomodulation of allergic diseases such as type I allergic disease conditions by the administration of modified allergens exhibiting reduced IgE interactivity while retaining T-cell antigenicity.

Recombinant allergen with reduced IgE binding but undiminished T-cell antigenicity

The present invention provides nucleic acid sequences coding Cyn d I, or at least one fragment thereof or the functional equivalent of such nucleic acid sequences. The present invention also provides expression vectors comprising such nucleic acid sequences and host cells transformed therewith. The present invention further provides isolated Bermuda grass pollen protein allergen Cyn d I or fragments thereof. Isolated Bermuda grass pollen protein allergens or antigenic or allergenic fragments thereof are useful for diagnosing and treating sensitivity in an individual to Bermuda grass pollen allergens.

Protein allergens of the species cynodon dactylon

The present invention relates generally to the use of genetic engineering to induce developmental regulation in anther tissue of plants, and more particularly to induce nuclear male sterility, and to genetic sequences useful for same. More particularly, the present invention relates to the identification of a genomic clone and promoter capable of tissue- and development-specific expression which provides a means of tissue and developmental regulation in plants and more specifically a means of producing nuclear male sterile plants. Even more particularly, the present invention provides a genomic clone having a nucleotide sequence as set forth in SEQ ID NO. 1 or homologous sequences thereof such as the nucleotide sequence as set forth in SEQ ID NO. 3.

Developmental regulation in anther tissue of plants

The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

Ryegrass pollen allergen

The present invention provides nucleic acid sequences coding Cyn dI, or at least one fragment thereof or the functional equivalent of such nucleic acid sequences. The present invention also provides expression vectors comprising such nucleic acid sequences and host cells transformed therewith. The present invention further provides isolated Bermuda grass pollen protein allergen Cyn dI or fragments thereof. Isolated Bermuda grass pollen protein allergens or antigenic or allergenic fragments thereof are useful for diagnosing and treating sensitivity in an individual to Bermuda grass pollen allergens.

Nucleic acid sequences encoding protein allergens of the species Cynodon dactylon

The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified LoI pIa and Lol pIb protein and fragments thereof, methods of producing recombinant Lol pIa and Lol pIb or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

Protein allergens of the species Cynodon dactylon

The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens,Ia and,Ib, purified,Ia and,Ib protein and fragments thereof, methods of producing recombinant,Ia and,Ib or at least one fragment thereof or derivative or homologue thereof, and methods of using the nucleic acid sequences, proteins and peptides of the invention.

Growing community of inventors

Templestowe, Australia

Mohan Bir Singh