Btg International Limited

Mohammed Sharief

Michael J Leach

Laurence Harbige

Paul Barraclough

Laurence S Harbige

A method is provided for treating a patient in need of therapy for a neurodegenerative disease comprising administering to that patient a therapeutically effective dose of a lipid glyceride comprising a glycerol moiety and a fatty acid moiety, the fatty acid moiety being selected from the group consisting of &#x3b3;-linolenic acid, dihomo-&#x3b3;-linolenic acid and arachidonic acid characterized in that the selected fatty acid moiety is attached to the glycerol moiety at its sn-2 position. Preferably the method is that wherein the lipid is administered for a duration and at a dose sufficient to maintain or elevate TGF-&#x3b2;1 levels in the patient to therapeutic levels.

Treatment of neurodegenerative conditions

Method for treating a patient in need of therapy for a neurodegenerative disease by administering to that patient a therapeutically effective dose of a triglyceride oil containing both &#x3b3;-linolenic acid and linolenic acid residues as triglyceride ester. The ratio of &#x3b3;-linolenic acid to linolenic acid residues at the sn-2 position of the triglyceride is at least 0.8. The amount of &#x3b3;-linolenic acid residues at the sn-2 position is at least 18%. The oil is administered at a dose sufficient to maintain or elevate TGF-&#x3b2;1 levels in the patient at a therapeutic level.

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Kent, United Kingdom

Mohammed Sharief