Centrose, LLC

Life Technologies Corporation

Promega Corporation

Ophidian Pharmaceuticals, Inc.

Mohammed Saleh Shekhani

James Robert Prudent

Charles R Hutchinson

Douglas C Stafford

Kurt William Vogel

Charles Vernon Pugh

Joseph R Firca

Thomas Livelli

Zhong Zhong

Stephen Hess

Robert W Schatz

Steve Duff

Nicholas Panasik, Jr

David Piper

Byron Anderson

The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.

Glycoside compounds and pharmaceutical compositions thereof

Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG Kchannel, and the propensity of a test compound to influence that binding interaction.

Fluorescence polarization hERG assay

Compositions and methods are described for preventing and treating sepsis in humans and other animals. Surgical patients, low birth weight infants, burn and trauma victims, as well as other individuals at risk can be treated prophylactically. Methods for treating acute infections with advantages over current therapeutic approaches are provided.

Polymyxin B conjugates

Diagnostics and treatments for bacterial infection are disclosed. The treatments prevent bacteria from adhering to host cells by interfering with the binding of the bacteria to cell receptors. Compounds that inhibit bacterial adherence to cells are engineered to be readily modified for best efficacy with different modes of treatment. The compounds can be readily modified for use to identify bacteria according to their cell binding specificities.

Compounds that bind bacterial pili

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Madison, WI, United States of America

Mohammed Saleh Shekhani