Njoy, Inc.

Mohammed Moinuddin Ahmed

Wesley Freund

Bert Willis

Douglas Sawyer

The present disclosure generally relates to methods of preparing nicotine and resolving R,S nicotine to enrich the (S)(&#x2212;) enantiomer. The method may comprise combining N-methyl-2-pyrrolidone or a salt thereof with a nicotinate compound in the presence of a solvent and a strong base to form 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof; and reducing the 1-methyl-3-nicotinoyl-2-pyrrolidone or salt thereof in solution with NaSOto produce racemic nicotine or salt thereof. Resolving the racemic nicotine (or other enantiomeric mixture) may comprise combining the nicotine with (&#x2212;)-O,O'-di-p-toluoyl-L-tartaric acid (L-PTTA).

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Brevard, NC, United States of America

Mohammed Moinuddin Ahmed