Intelligent Virus Imaging Inc

Vironova Influenza Ab

Other

Vironova Herpes Ab

Intelligent Virus Imagaing Inc.

Vironova Ab

Mohammed Homman

Jan Bergman

Ida-Maria Sintorn

Martin Ryner

Ngarita Kingi

Robert Berg

Robert Engovist

Robert Engqvist

Cecilia E Söderberg-Nauclér

Cecilia Soderberg-Naucler

Cecilia Söderberg-Nauclér

A pharmaceutical composition for topical administration including 2,3-dimethyl-6-(N,N-dimethylaminoethyl)-6H-indolo-(2,3-b)quinoxaline(B-220) or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier The composition is useful for the treatment of herpes virus infections of the skin or mucous membranes in a mammal subject.

Pharmaceutical formulation comprising 2,3-dimethyl-6-(N,N-dimethylaminoethyl)-6H-indolo-(2,3-B)quinoxaline

Thiol derivatives of general formula (II) have antiviral activity, particularly against influenza virus.  In particular, the compound (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(4-(2-fluoro-6-methoxyphenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methanone is provided. Methods of preparing the compounds are also described.

Compounds and methods

A compound of formula (I) is useful as an antiviral agent, in particular for the treatment of influenza. A method for preparing the compound of formula (I) and a composition including the compound of formula (I) are described.

Methanethione compounds having antiviral activity

A pharmaceutical composition for topical administration including 2,3-dimethyl-6-(N,N-dimethylaminoethyl)-6H-indolo-(2,3-b)quinoxaline (B-220) or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier. The composition is useful for the treatment of herpes virus infections of the skin or mucous membranes in a mammal subject.

Pharmaceutical formulation for treating herpes virus infection comprising 2,3-dimethyl-6-(N,N-dimethylaminoethyl)-6H-indolo-(2,3-b) quinoxaline

The method is for the identification and characterization of structures in electron micrographs. Structures in a first image are selected. The structures have a first shape type deformed in a first direction. The selected structures are transformed to a second shape type different from the first shape type. The transformed structures of the second shape type are used to form a plurality of templates. A new structure in a second image is identified. The new structure has the first shape type. The second shape type structure of each template is deformed in the first direction. It is determined which template is a preferred template that best matches the new structure.

Identification and classification of virus particles in textured electron micrographs

The method is for intracellular counting and segmentation of viral particles or infectious agents in an image. An image is provided that has a plurality of items therein. A radius range of viral particles is determined. Items in the image having a radius within the predetermined radius range are identified. Elliptical items that are formable from the predetermined radius range are determined. The round and elliptical items identified into groups are sorted. The viral particles among the round and elliptical items are identified. For example, the method may be used for intracellular counting and segmentation of siRNA treated human cytomegaloviral particles in TEM images.

Method for counting and segmenting viral particles in an image

A cell is provided that contains a plurality of virus particles. A first image of a first virus particle and a second image of a second virus particle are taken by electron microscopy technology. The first virus particle is characterized as being in a first maturity stage and the second virus particle as being in a second maturity stage. The first image and the second image are transformed to first and second gray scale profiles, respectively, based on pixel data. The first and second gray scale profiles are then saved as first and second templates, respectively. A third virus particle in a third image is identified. The third image is transformed into a third gray scale profile. The third gray scale is compared to the first and second template to determine a maturity stage of the third virus particle.

Method of analyzing cell structures and their components

The method is for intracellular counting and segmentation of viral particles in an image. An image is provided that has a plurality of items therein. A radius range of viral particles is determined. Round items in the image having a radius within the predetermined radius range are identified. Elliptical items that are formable from the predetermined radius range are determined. The round and elliptical items identified into groups are sorted. The viral particles among the round and elliptical items are identified. For example, the method may be used for intracellular counting and segmentation of siRNA treated human cytomegaloviral particles in TEM images.

A compound of formula (I) wherein Ris selected from H, F, Cl, Br, CF, C-Calkoxy and OH; Ris selected from H and C-Calkyl; n is 1-12; m is O or 1; Y is selected from CH, NR, (NRR)+X, O and S; Rand Rare independently selected from H and C-Calkyl; and X&#x2033; is selected from phannaceutically acceptable anions. A method of preparing the compound, its use as a pharmaceutical, and a method of treatment. 

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Nacka, Sweden

Mohammed Homman