Chemagis Ltd.

Mohammed Alnabari

Joseph Kaspi

Oded Arad

Yana Sery

Ori Lerman

Michael Brand

Itai Adin

Edna Danon

Lior Zelikovitch

Olga Etlin

Moty Shookrun

Moshe Bentolila

Irina Gribun

Ada Salman

Meital Shiffer

Orna Kurlat

The present invention provides a process for preparing highly pure Temozolomide base which includes recovery from the purification mother liquors by using an anionic exchange resin. By treating Temozolomide hydrochloride with a mixture of an organic acid, a water miscible organic solvent, and water, Temozolomide free base is obtained in an acidic medium. Due to the high sensitivity of Temozolomide to basic pH values the recovery-including process is especially advantageous because it enables obtaining high yields of highly pure Temozolomide base in acidic conditions. The process for producing Temozolomide base includes hydrolysis of the starting material 8-cyano-3-methyl-[3H]-imidazo[5,1-d]-tetrazin-4-one in acidic medium to obtain highly pure Temozolomide hydrochloride in high yield.

Process for preparing temozolomide

The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.

Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride

An amorphous form of montelukast sodium and a montelukast sodium lactose co-precipitate, processes for producing same, pharmaceutical compositions containing same and methods of treatment utilizing same are disclosed.

Stable amorphous forms of montelukast sodium

The invention provides a process for the preparation of a compound of the formula 6 comprising the hydrolysis and decarboxylation of a compound of the formula 5 according to the reaction:wherein R and Rindependently a C-Calkyl group or an aralkyl group.

Process for the preparation of donepezil

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Hura, Israel

Mohammed Alnabari