Eli Lilly and Company

Mohammad Sadegh Zia-Ebrahimi

David Anthony Barda

Sonia Maria Gutierrez Sanfeliciano

Paul Luther Skatrud

Michael J Rodriguez

James Allen Monn

David Andrew Coates

Bruce Anthony Dressman

Jolie Anne Bastian

James Robert Henry

Larry C Blaszczak

Deqi Guo

Steven Scott Henry

Richard Duane Johnston

Steven Marc Massey

Scott C Mauldin

Sheng-Bin Peng

Gaiying Zhao

Almudena Rubio

Francisco Javier Agejas-Chicharro

Jason Eric Lamar

Kelly Wayne Furness

Jose Antonio Martinez Perez

Santiago Carballares Martin

Chong Si

Tao Liu

Wenceslao Lumeras Amador

Isabel Rojo

Michael Scott VanNieuwenhze

Pablo Garcia Losada

William Ernest Alborn, Jr

Ryan James Linder

Mario Barberis

Victoriano Molero Florez

Maria Lourdes Prieto Vallejo

Matthew Patrick Baumgartner

The present invention provides compounds of the formula:

KRas inhibitors

The present invention provides compounds of the Formula I below where R1, R2 and m are as described herein, pharmaceutically acceptable salts of the compounds of Formula 1, and methods of using these compounds and salts for treating patients for cancer.

KRas G12C inhibitors

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C-Calkyl, C-Calkoxy, C-Cacyl, halo, amino, nitro, cyano, hydroxy, C-Cacylamino, C-Calkylsulfonylamino, mono-, di- or trifluorinated C-Calkyl, substituents which may be the same or different and may bear a CONH, CONHCH, CON(CH), COH, COCH, OCF, CHNHCOCH, CHNH, CHN(CH), CHCN, CHOH, CHNHSOCH, CHN(CH)(CH)CN, CHN(CH)CH(CH), CHNHCH(CH), CHNH(CH)CH, CHNHCOR, CHNHCHCH, CHNHCHNHCOC(CH), or N(S(O)CH)substituent; Ris hydrogen, halo, R, CN, C(NOH)R, C(NO&#x2014;R)R, (CH)COR, (CH)OR, COR, CF, SR, S(O)R, S(O)R, COCHCOR, NHSOR, NHCOR, C(NOR)NH, CHOCOR, (CH)NH, CON(CH)(CH)NHCOR, COR, CONH, CSNH, C(NH)NHOR, (CH)N(CH), or CONHNHCOR; Ris 1,2-ethenediyl or 1,2-ethynediyl; Ris hydrogen or C-Calkyl; Ris C-Calkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof. 

Pyridyl derivatives and their use as mGlu5 antagonists

A process is described for preparing a substrate for the transglycosylase enzymes of bacterial cell wall biosynthesis. The chemical synthesis makes available a sustainable and substantially pure source of supply of lipid II, including analogs thereof, that may be used in the identification of new therapeutic agents capable of disrupting steps in bacterial cell wall biosynthesis.

Process for preparing lipid II

This invention provides new stabilized methylene Meldrum's acid precursors, a process for their preparation, and a process for using such compounds in the preparation of methylene Meldrum's acid.

Methylene meldrum's acid precursors

Growing community of inventors

Indianapolis, IN, United States of America

Mohammad Sadegh Zia-Ebrahimi