Geron Corporation

Recyte Therapeutics, Inc.

Asterias Biotherapeutics, Inc.

Mohammad Hassanipour

Joseph D Gold

Chunhui Xu

Dana Larocca

Paola A Bignone

Lila R Collins

The invention provides methods, compositions, uses and kits relating to exosomes isolated from progenitor cells.

Exosomes from clonal progenitor cells

The present application describes the new methods for the differentiation of primate pluripotent stem cells into cardiomyocyte-lineage cells. The methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce cardiomyocyte-lineage cells. In certain embodiments of the invention, the population of cells produced by the sequential culturing is further enriched for cardiomyocyte-lineage cells so as to produce a higher percentage of those cells.

Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells

This invention provides a new procedure for generating cardiomyocyte lineage cells from embryonic stem cells for use in regenerative medicine. Differentiating by way of embryoid body formation or in serum is no longer required. Instead, the stem cells are plated onto a solid substrate, and differentiated in the presence of select factors and morphogens. After enrichment for cells with the appropriate phenotype, the cells are allowed to cluster into Cardiac Bodies&#x2122;, which are remarkably homogeneous and suitable for the treatment of heart disease.

Direct differentiation method for making cardiomyocytes from human embryonic stem cells

This invention provides a new procedure for generating cardiomyocyte lineage cells from embryonic stem cells for use in regenerative medicine. Differentiating by way of embryoid body formation or in serum is no longer required. Instead, the stem cells are plated onto a solid substrate, and differentiated in the presence of select factors and morphogens. After enrichment for cells with the appropriate phenotype, the cells are allowed to cluster into cardiac bodies&#x2122;, which are remarkably homogeneous and suitable for the treatment of heart disease.

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Danville, CA, United States of America

Mohammad Hassanipour