Tenaya Therapeutics, Inc.

Mohammad A Mandegar

Julio Cesar Medina

Snahel Patel

Ulhas Bhatt

Tien Widjaja

Alok Nerurkar

David Sperandio

Frederick Seidl

Jin Yang

Timothy C Hoey

Martin Holan

Yihong Li

John Lee

Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.

Fluoroalkyl-oxadiazoles and uses thereof

Provided herein are methods of treating or preventing metabolic disease with an HDAC6 inhibitor. Also provided herein are methods of treating or preventing heart failure with preserved ejection fraction with an HDAC6 inhibitor. A variety of HDAC6 inhibitors are described herein for use in treating or preventing metabolic disease or heart failure with preserved ejection fraction. In one aspect, described herein are methods of treating a human patient by orally administering an HDAC6 inhibitor, such as an inhibitor of Formula (I) or Formula (II).

HDAC6 inhibitors for treatment of metabolic disease and HFpEF

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South San Francisco, CA, United States of America

Mohammad A Mandegar