Dr. Reddy's Laboratories, Incorporated

Aurigene Discovery Technologies Limited

Um Pharmauji Sdn. Bhd.

Aurigene Oncology Limited

Mohamed Takhi

Subramanya Hosahalli

Sunil Kumar Panigrahi

Javed Iqbal

Sreenivas Kandepu

Natesan Selvakumar

Muni Kumar Mahadari

Chandrashekar Reddy Kottam

Noorsaadah Abd Rahman

Rohana Yusof

Gavara Govinda Rajulu

The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particularly FabI inhibitors. Formula (I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. 

Substituted pyridine derivatives as FabI inhibitors

The present invention relates to tetrahydropyridine derivatives of formula (1) which may be therapeutically useful as anti-bacterial agents, more particularly FabI inhibitors. in which X, Y, Z and 'n' have the same meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting Enoyl-ACP reductase enzyme (FabI) activity. The present invention also provides methods for synthesizing and administering the FabI inhibitory compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitory compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Tetrahydropyridine derivatives as FabI inhibitors

In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm blooded animals employing these new compounds. 

Tetracycline derivatives as antibacterial agents

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Hyderabad Telangana, India

Mohamed Takhi