International Business Machines Corporation

Mohamed Ghalwash

Daby Mousse Sow

Ping Zhang

Sanjoy Dey

Qinghuang Lin

Pritish Ranjan Parida

Ying Li

Kenney Ng

James V Codella

Zijun Yao

Vibha Anand

Prithwish Chakraborty

Techniques for generating an ontology based on biomarker information associated with persons to facilitate improving clinical predictions relating to medical conditions are presented. An ontology generator component (OGC) can extract clinical features associated with patients and their associated times from medical records or databases to develop clinical profiles associated with the patients and relating to a medical condition. OGC can develop an ontology relating to the medical condition, including progression and severity of biomarkers associated with the medical condition, based on the clinical profiles and domain knowledge information relating to the medical condition. OGC can determine global features relating to progression and severity associated with the medical condition based on the ontology. At a forecasting point, the global features can be extracted from the ontology and applied to a prediction model to enhance prediction of onset of, or progression of, the medical condition for a patient.

Generating ontology based on biomarkers

Techniques regarding neuromodulation are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can include a mapping component that can generate a stimulus map by mapping a stimulus parameter to a response from an entity to application of a neuromodulating stimulus, with the first neuromodulating stimulus being applied to the entity based on the first stimulus parameter, to therapeutically cause or prevent a sensation.

Neurostimulation therapy

Systems and methods that use multi-tasking and transfer learning with sparse gating mechanisms and domain knowledge to generate pheno-embeddings in a scalable manner that can improve the relevance of the patient embeddings from Electronic Health Records. A system, comprises at least one processor that executes the following computer executable components stored in memory: a structural pheno-embedding model that employs a hierarchical knowledge graph; a data augmentation component that expands on a sparse data set associated with the knowledge graph; and an embedding component that generates a specialized embedding for phenotypes using the structural pheno-embedding model and the augmented data set for a selected cohort.

System for generating specialized phenotypical embedding

Mechanisms are provided for implementing a framework to learn multiple drug-adverse drug reaction associations. The mechanisms receive and analyze patient electronic medical record data and adverse drug reaction data to identify co-occurrences of references to drugs with references to adverse drug reactions (ADRs) to thereby generate candidate rules specifying multiple drug-ADR relationships. The mechanisms filter the candidate rules to remove a subset of one or more rules having confounder drugs specified in the subset of one or more candidate rules, and thereby generate a filtered set of candidate rules. The mechanisms further generate a causal model based on the filtered set of candidate rules. The causal model comprises, for each ADR in a set of ADRs, a corresponding set of one or more rules, each rule specifying a combination of drugs having a causal relationship with the ADR.

Finding precise causal multi-drug-drug interactions for adverse drug reaction analysis

Growing community of inventors

Yorktown Heights, NY, United States of America

Mohamed Ghalwash