Ortho-Mcneil Pharmaceutical Corp.

Incyte San Diego Inc.

Mohamed Boudjelal

Catherine Tachdjian

Magnus Pfahl

Hussien A Al-Shamma

Lyle W Spruce

Torsten R Wiemann

Andrea Fanjul

David P M Pleynet

James Zapf

Jianhua Guo

Karine Jakubowicz-Jaillardon

Andrea Fanjul Giachino

The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Arform a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.

Heterocyclic amide derivatives for the treatment of diabetes and other diseases

The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia: 

N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseases

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San Diego, CA, United States of America

Mohamed Boudjelal