The University of North Carolina at Chapel Hill

Florida State University Research Foundation, Inc.

Mohamed A Ismail

Richard Ray Tidwell

David W Boykin

W David Wilson

Reto Brun

Karl Werbovetz

Reem K Arafa

Laixing Hu

Chad F Stephens

Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. The compounds include those of Formula (III): wherein one of A, Y, and Zis N; Aris phenylene; and Aris a nitrogen-containing aromatic group. An exemplary compound of Formula (III) is: 

Substituted pyridines as antiparasitic AZA teraryl compounds

Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. Also described are processes for synthesizing the compounds. The presently disclosed compounds can include those of the formulas:  Land Lare selected from the group consisting of: 

Linear dicationic terphenyls and their aza analogues as antiparasitic agents

Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): wherein p and q are each 0 and each A, Y and Z is CR. An exemplary compound of Formula (IIe) is: Methods for combating microbial infections, such as parasiticspecies, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.

Teraryl components as antiparasitic agents

Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus, orcomparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of ainfection.

Bichalcophenes and their prodrugs as antiprotozoal agents

A method for treating a microbial infection, including an infection from a protozoan pathogen, such asand, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.

Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents

A compound of Formula (I): wherein: wherein n is a number from 1 to 3, and Ris H or &#x2014;CONHRNRR, wherein Ris lower alkyl and Rand Rare each independently selected from the group consisting of H and lower alkyl.

Growing community of inventors

Atlanta, GA, United States of America

Mohamed A Ismail