King Abdulaziz University

Mohamed A El-Zahabi

Abdelsattar Mansour Omar

Moustafa Elsayed El-Araby

Ashraf B Abdel-Naim

Salah G Atteiah

Compounds for the treatment of hyperglycemia and/or diabetes are provided. The compounds, which inhibit the enzyme dipeptidyl peptidase (DPP-4), are based on the structure where n1=0-2 such as 0 or 1; R1 is i) a saturated or unsaturated, substituted or unsubstituted monocyclic aliphatic ring, alone or fused with cyclopropane or cyclobutene, optionally comprising one or more substituents attached to the ring; or ii) a substituted or unsubstituted monocyclic aromatic ring, optionally comprising one or more substituents attached to the ring; R2 is present or absent and if present is: C&#x2550;O; (CH)where n=0-4; S; SO; SO; NR where R&#x2550;H, CHor CHCH; or NH(CH)where n=0-4; and R3 is present or absent and if present is (CH)where n=0-4; S; SO; SO; NR where R&#x2550;H, CHor CHCH; or NH(CH)n where n=0-4; and salts and isomers thereof.

Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics

Compounds for the treatment of hyperglycemia and/or diabetes are provided. The compounds, which inhibit the enzyme dipeptidyl peptidase (DPP-4), are based on the structure where X may be present or absent an may be OH, Ar is an aryl group; and n ranges from 0 to 5.

Growing community of inventors

Cairo, Egypt

Mohamed A El-Zahabi