The Johns Hopkins University

Mohamad Allaf

Martin Gilbert Pomper

Ronnie Charles Mease

Dan Stoianovici

Sangeeta Ray

Xing Yang

Louis R Kavoussi

Steven M Rowe

Il Minn

Michael Gorin

Stephen Jackman

Steven Rowe

Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.

Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase IX and uses thereof

An electrical impedance probe is provided that includes a surgical needle. In an exemplary embodiment, the probe is a two-part trocar needle designed to acquire impedance measurements at its tip. The impedance measurements are representative of the local properties of a biological substance at the needle tip. Thus, the probe may be used to confirm needle insertion into a desired anatomical target or to identify the nature of the cells surrounding the tip of the needle. In urology, this sensor is used for confirming the needle insertion into the urinary tract, for localizing renal cell carcinoma, and prostate cancer.

Surgical needle probe for electrical impedance measurements

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Baltimore, MD, United States of America

Mohamad Allaf