H. Lundbeck A/s

Neurosearch A/s

Lica Pharmaceuticals A/s

Mogens Larsen

Gunnar M Olsen

Benny Bang-Andersen

Simon Feldbæk Nielsen

Thomas Boesen

Tina Holm Johansen

Gitte Kobberoee Mikkelsen

Thomas Varming

Claus Mathiesen

Hasse Kromann

Elsebet Østergaard Nielsen

Alex Haahr Gouliaev

Anette Graven Sams

Jørgen Scheel-Krüger

Jorgen Scheel-Kruger

Annette Graven Sams

Kristian Schønning

Mette Bjerg Nielsen

Alex Haaht Gouliaev

Elsesbet Ostergaard Nielsen

The Invention relates to compounds of the formula I, wherein the variables are as defined in the claims, for use as a medicament. The compounds are A-receptor legends and are useful in the treatment of neurological and psychiatric disorders where an A-receptor is implicated.

2-acylaminothiazole derivatives

The invention relates to compounds of the formula IA-B-Z &#x2003;&#x2003;Iwherein the variables are as defined in the claims. The compounds are pro-drugs of A-receptor ligands with improved aqueous solubility, and are useful in the treatment of neurological and psychiatric disorders where an A-receptor is implicated.

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The invention provides novel diamino-functionalized chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic and bacteriostatic agents.

Diamino-functional chalcones

The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, bacteriostatic, and bacteriocidal agents.

Aminoalkoxy-functional chalcones

The invention provides novel compounds represented by the general formula compound represented by the formula: wherein The compounds are useful as positive modulators of the AMPA-receptor.

Compounds and their use as positive AMPA receptor modulators

The invention provides novel compounds represented by general formula (I)wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R; X represents SOor C&#x2550;O of CH; Y represents &#x2014;CH(R)&#x2014;, &#x2014;N(R)&#x2014;CH&#x2014;, O; and the meaning of R, R, R, R, R, R, and Rare as defined in the application. The compounds are useful as positive modulators of the AMPA-receptor.

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Smorum, Denmark

Mogens Larsen