University of Colorado

Mo Zohrabi

Victor M Bright

Juliet T Gopinath

Robert H Cormack

Omkar D Supekar

Wei Yang Lim

Emily A Gibson

Connor McCullough

The present disclosure relates generally to methods and systems useful in imaging applications, especially biological imaging applications, and applications in the metrology, atmospheric, scientific and medical fields. In one aspect, the disclosure provides a method of imaging an object, including illuminating the object with incident radiation through one or more adaptive optical elements; receiving transmitted radiation from the object at a photodetector to provide a base image; and performing the following steps one or more times: adjusting the one or more adaptive optical elements, the adjustment including modifying an optical transfer function of the one or more adaptive optical elements, and receiving transmitted radiation from the object at the photodetector to provide an adjusted image; wherein the adjustment and receiving steps are performed until the adjusted image has substantially reduced aberrations compared to the base image.

Methods and systems for imaging with aberration correction

A tunable optical electrowetting element having a liquid-liquid interface shape controlled by an applied voltage. Circuitry for applying a voltage to the electrowetting element is configured to apply a shaped voltage signal comprising a first fast-rising signal combined with a second fast-rising signal. The second signal is selected to damp oscillations in the liquid-liquid interface caused by the first signal.

Enhanced response time of tunable optical electrowetting elements with shaped input voltage functions

A system for high resolution multiphoton excitation microscopy is described herein. In one embodiment, the system may include an electrowetting on dielectric (EWOD) prism optically coupled to an excitation source, the EWOD prism adapted or configured to: receive a light beam from the excitation source, and project the received light beam onto a sample plane based on a tunable transmission angle of the EWOD prism, and a fluorescence imaging microscope adapted or configured to: receive a fluorescence signal from the sample plane based on the projected light beam, and relay the fluorescence signal from the sample plane to a set of detectors.

Electrowetting prism for scanning in high resolution fluorescence microscopy

Wide-angle beam steering using two or more variable lenses to form a small-angle beam steering element, along with a numerical aperture converter and a wide-angle lens. The small-angle beam steering element might comprise either one- or two-dimensional beam steering with tunable liquid lenses.

Growing community of inventors

Boulder, CO, United States of America

Mo Zohrabi