Clear Creek Bio, Inc.

Mo Jia

Ping Huang

David Paul Hesson

Xianjun You

Vikram S Kumar

Siyi Jiang

Qingqing Lu

Chaoyi Deng

Abdolsamad Tadayon

Lin Cui

Jinsuo Yang

The invention provides compositions containing a stable crystalline form of brequinar and methods of making such composition. The invention also provides methods of using such compositions to treat a condition in a subject.

Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof

The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2'-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Compositions and methods for inhibiting dihydroorotate dehydrogenase

The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2'-halo-1-1&#x2032;-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

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Shanghai, China

Mo Jia