Eisai R&d Management Co., Ltd.

Other

Eisai Company, Limited

Sumitomo Bakelite Company Limited

River Seiko Limited Company

Miyuki Nishimura

Toshio Imai

Yoshimasa Sakamoto

Tetsu Kawano

Kenzo Muramoto

Luigi Grasso

Jared Spidel

Tatsuo Horizoe

Yuichi Ono

Yoshimi Takai

Yoshikazu Kuboi

James Bradford Kline

Masakazu Takeuchi

Mayumi Asano

Koji Morimoto

Yoko Inoue

Hideaki Ogasawara

Haruhiko Masuda

Yoshihisa Arita

Shinetsu Harada

Akira Harada

Yoshiaki Okada

Yukihisa Sawa

Keiko Mizuno

Brad Kline

The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Neutralizing anti-CCL20 antibodies

An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.

Anti-human XCR1 antibodies

Nucleic acids encoding neutralizing anti-CCL20 antibodies

The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.

Compositions and methods for treating inflammatory disorders

Provided is a bipolar high frequency treatment device including a catheter tube insertable into a body through a treatment device passage of an endoscope; a first forceps blade and a second forceps blade at the top end of the catheter tube, which first forceps blade and second forceps blade can be opened and closed by operating from outside the body; a support member for supporting the first forceps blade and the second forceps blade so that the blades are able to open and close; and a voltage supplier for supplying a high frequency voltage to the first forceps blade and the second forceps blade, wherein the first forceps blade and the second forceps blade are electrically insulated with an insulating element.

Bipolar high frequency treatment device

A therapeutic agent for an inflammatory disease comprising an antibody or a CX3CR1 antagonist that inhibits an interaction of fractalkine and CX3CR1 is provided.

Treating inflammatory diseases with antibodies that inhibit fractalkine-CXCR1 interaction

A clipping instrument for biological tissues equipped with an outer tube which can be inserted into a biological cavity, an operating member freely passed through the outer tube, an operating wire freely passed though the operating member, a self-opening holder which can be opened and closed by the action of the operating member attached to the edge of the operating wire, and a self-opening clop having a clipping member for clopping a biological tissue which is attached to the edge of the holder in a detachable manner by opening/closing the holder. Using this clopping instrument, a lesion site can be surely clipped over a long period of time in ligating a breeding site in a biological tissue, stitching a laceration, making in excision of a mucosal tissue and so on with an endoscope.

Clip and clipping instrument for biological tissues

Endoscopic treatment device

Treating instrument for an endoscope

A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.

Exocrine gland tight junction-constituting protein jeap family

There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotoxic activity of killer lymphocytes by suppressing an interaction between CX3CR1 and fractalkine.

Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine

A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.

Growing community of inventors

Kobe, Japan

Miyuki Nishimura