Tokyo Medical and Dental University

Tokai National Higher Education and Research System

Megmilk Snow Brand Co., Ltd.

Miyako Tanaka

Akira Matsumoto

Yuji Miyahara

Hiroko Matsumoto

Takayoshi Suganami

Ken Kato

Noriko Ueda

Toshimitsu Yoshioka

Yuki Morooka

A sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug such as insulin.

Temperature-resistant sugar-responsive gel

An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.

Drug delivery device

Growing community of inventors

Nagoya, Japan

Miyako Tanaka