Commonwealth Scientific and Industrial Research Organisation

Mittur N Jagadish

Ahmed Abdullah Azad

Kevin John Fahey

Neil Moreton McKern

Paul Richard Vaughan

Hans-Georg Heine

Antony J Chapman

Ian G Macreadie

A highly immunogenic form of the VP2 structural protein of IBDV comprises a high molecular weight aggregated form of VP2 produced by the expression of a nucleotide sequence coding for the VP2 structural protein or a polypeptide displaying the antigenicity of all or a part of the VP2 structural protein in a yeast or other eukaryotic host cell.

Production of IBDV VP2 in highly immunogenic form

A recombinant DNA molecule comprising a nucleotide sequence coding for a conformational epitope of the VP2 polypeptide of IBDV. In particular, a DNA molecule comprising a sequence which substantially corresponds to the AccI-SpeI fragment, and optionally the ScaI-XhoI fragment, of the IBDV genome segment coding for the VP2 polypeptide. Synthetic peptides or polypeptides, including fused polypeptides, prepared by expression of host cells containing these DNA molecules are also disclosed, as well as compositions for stimulating an immune response against IBDV comprising at least one such synthetic peptide or polypeptides.

IBDV VP2 epitope recognized by virus neutralizing and protective

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Melbourne, Australia

Mittur N Jagadish