Kao Corporation

Mitsuyoshi Sakasai

Hiroshi Kusuoku

Azumi Nagasawa

Shigeru Moriwaki

Kentaro Kumihashi

Noriko Ito

Michiyo Sasajima

Tomohiro Shirai

Megumi Matsuoka

Hiroshi Hashimoto

Mayumi Sato

Yusuke Shibuya

Minoru Takizawa

The present invention provides a processed plant product having an excellent TRPM8 activating action, a method for producing the same, and a cooling agent and a TRPM8 activator comprising the processed plant product. A method for producing a processed nutmeg product, comprising a step of simultaneously treating nutmeg or an extract thereof with an alcohol or a 25% (v/v) or more alcohol aqueous solution and one or more selected from a protonic acid and an H-type cation exchange resin.

Processed nutmeg product and method for producing same

Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein Rrepresents a hydrogen atom; Rrepresents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or a hydroxyl group; Rrepresents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and Rrepresents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

Cooling agent and TRPM8 activator

To provide a drug, an external use composition, and a cosmetic composition, which exhibit an NFAT signal inhibitory action, a calcineurin inhibitory action, and a hair growth-promoting effect. The NFAT signal inhibitor contains, as an active ingredient, American angelica or an extract thereof.

NFAT signal inhibitor and calcineurin inhibitor

An NFAT signal inhibitor and the like are provided. An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where in the formula (I), Rand R, which may be identical with or different from each other, each represent a hydrogen atom or a group represented by formula (II) (where in the formula (II), Rrepresents a linear or branched alkyl or alkenyl group having 1 to 20 carbon atoms)] and pharmacologically acceptable salts thereof.

NFAT signal inhibitor and hair-growing agent

To provide a lipolysis agent, a slimming agent, and a cellulite-ameliorating agent, which stimulate decomposition of fat accumulated in the adipose tissue, to thereby exhibit body-slimming effect and which is effective for inhibition or prevention of obesity and amelioration of prone to obesity. The lipolysis stimulator of the invention contains, as effective ingredients, a plant Huang Hua Cai or an extract thereof, and a xanthine derivative.

Growing community of inventors

Kawasaki, Japan

Mitsuyoshi Sakasai