Fujisawa Pharmaceutical Company, Ltd.

Nissan Chemical Industries Limited

Zeria Pharmaceutical Co., Ltd.

Mitsuyoshi Nakashima

Mitsutaka Kanamaru

Masato Terakawa

Akira Sugiyama

Misao Miyamoto

Haruo Horiai

Yutaka Kohno

Takaharu Ono

Kazuo Umemura

Nobuyuki Kikuchi

Toshihiko Uematsu

The invention relates to a method for improving inner ear microcirculation, which comprises administering an effective amount of a dihydropyridine compound of the general formula: ##STR1## wherein R.sup.1 is a nitrophenyl group; and R.sup.2, R.sup.3 and R.sup.4 each is a lower alkyl group, or a pharmaceutically acceptable salt thereof to a human or animal.

Use of a dihydropyridine compound for improving inner ear

A blood platelet-decreasing therapeutic drug comprising as an effective ingredient a 3(2H)-pyridazinone compound of the formula (I): ##STR1## wherein each of R.sup.1 and R.sup.2, which are independent of each other, is a hydrogen atom or a C.sub.1-4 alkyl group, and X is a chlorine atom or a bromine atom, or a pharmaceutically acceptable salt thereof.

Blood platelet-decreasing method

A method for treating edema or hypertension which comprises administering an effective amount of a quinazoline derivative of the general formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each is a hydrogen atom or a halogen atom or a pharmaceutically acceptable salt thereof to a human being in need of said treatment.

Diuretic or antihypertensive composition

The invention relates to a method for preventing and/or treating gout and hyperuricemia which comprises administering a uricosuric effective amount of a quinazoline derivative of the general formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each is a hydrogen atom or a halogen atom or a pharmaceutically acceptable salt thereof to a human being in need thereof.

Uricosuric composition

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Hamamatsu, Japan

Mitsuyoshi Nakashima