National Institute of Advanced Industrial Science and Technology

Japan Science and Technology Agency

Japan Science and Technology Corporation

Seed Company Limited

Chugoku Marine Paints, Ltd.

Mitsutoshi Masuda

Toshimi Shimizu

Takao Sato

Hideyuki Tanaka

Yoshiko Yamazaki

Jyunji Niimoto

Wuxiao Ding

Momoyo Wada

George John

Naohiro Kameta

Hiroyuki Minamikawa

Rika Iwamura

Yutaka Fujiki

Yasuyuki Seki

The purpose of the present invention is to provide: a functional polymer gel which is able to be practically used as an ocular lens having excellent transparency and mechanical strength by uniformly dispersing organic nanotubes in a polymer gel without the formation of agglomerates of the organic nanotubes in the case where the organic nanotubes are complexed into the polymer gel; and a method for producing this functional polymer gel. The above-mentioned purpose is achieved by: a functional polymer gel which is characterized by containing organic nanotubes and having a light transmittance of 80% or more; and a method for producing this functional polymer gel.

Functional polymer gel containing organic nanotubes and method for producing same

Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus, In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22. Particularly, an asymmetric bipolar lipid molecule and an ester thereof respectively represented by general formulae (1) and (2) wherein n is an integer of 18 to 22, both of Zand Zare single bonds, Y is Gly, m(s) is the same or different integer of 3 to 6, X is OH, and R is a methoxy group, an ethoxy group, or a benzyloxy group are novel substances, and can form a carboxylic acid based asymmetric nanotube by single component self-assembly or binary self-assembly.

Organic nanotube having hydrophobized inner surface, and encapsulated medicinal agent prepared using the nanotube

A gelatinizer is provided having a component which promises to have biological compatibility, which can easily be mass-produced by a simple method, and which can solidify a large amount of water or aqueous solution when only a very small weight of it is used. This invention is a hydrogelatinizer represented by the general formula:R-Awhere A, which may be identical or different, are respectively nucleotides, n is 2 or 3, and R is a hydrocarbon chain (when n is 2, R is bivalent, and when n is 3, R is trivalent), said hydrocarbon being bonded to a phosphoric acid part of said nucleotides.

Hydrogelation agents

The present invention is a stable, nanometer scale micro-tubular aggregated material of an asymmetric double-headed lipid represented by the general formulaR&#x2014;NHCO&#x2014;(CH)&#x2014;COOH&#x2003;&#x2003;(I)(in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty). The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 &#x3bc;m. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100&#xb0; C. to dissolve it and then gradually cooling the aqueous solution obtained.

Asymmetrical bicipital lipid and tubular aggregate formed by using the same

Hollow fibrous organic nanotube and method for producing the same

Growing community of inventors

Ibaraki, Japan

Mitsutoshi Masuda