Hoffmann-la Roche Inc.

Mitsuru Tateishi

Richard W Kierstead

Hans Bruderer

Jay P O'Brien

John G Mullin

Keiji Nakamura

Sidney Teitel

Teitel Sidney

Substituted isoquinolines of the formula ##STR1## wherein R is a lower alkoxy, n is the integer zero or 1, and

Substituted isoquinolines

Substituted isoquinolines of the formula ##STR1## wherein R is lower alkoxy, n is the integer zero or 1, and A is ##STR2## wherein R.sub.1 is phenyl, halophenyl, lower-alkylphenyl or lower-alkoxyphenyl, and pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I are useful in the treatment of cerebral and cardiac ischemias.

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Atsugi, Japan

Mitsuru Tateishi