Takeda Pharmaceutical Company Limited

Mitsuru Sasaki

Hiroyuki Kimura

Shuji Kitamura

Fumio Itoh

Tomohiro Kawamoto

Hideki Igata

A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is &#x2014;O&#x2014;, &#x2014;N&#x2550;, &#x2014;NR&#x2014; or &#x2014;CHR&#x2014;, Ris an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and Ris a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.

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Takatsuki, Japan

Mitsuru Sasaki