Mitsubishi Pharma Corporation

Sanofi-Aventis

Mitsubishi Tanabe Pharma Corporation

Sanofi-Synthelabo

Mitsuru Ooizumi

Masahiro Okuyama

Kazutoshi Watanabe

Fumiaki Uehara

Yoshihiro Usui

Aya Shoda

Keiichi Aritomo

Shinsuke Hiki

Akira Nakao

Haruko Yamabe

Koichi Yamakoshi

Ken-ichi Saito

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1: wherein Rrepresents a C-Calkyl group which may be substituted;R represents, for example, a group represented by the following formula (II): wherein Rand Rindependently represent a hydrogen atom or a C-Calkyl group;Rrepresents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.

3-Substituted-4-pyrimidone derivatives

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1: wherein Rrepresents a C-Calkyl group which may be substituted; R represents, for example, a group represented by the following formula (II): wherein Rand Rindependently represent a hydrogen atom or a C-Calkyl group; Rrepresents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, and having 5 to 10 ring-constituting atoms in total. 

3-substituted-4-pyrimidone derivatives

Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an aryl group, a heterocyclic group or the like; Q represents a group represented by &#x2014;CH&#x2014;, &#x2014;CO&#x2014;, &#x2014;O&#x2014;, &#x2014;CH(OR)&#x2014; or the like wherein Rrepresents a hydrogen atom, an alkyl group or the like; n represents an integer of from 0 to 5; Rand Reach represent a hydrogen atom, an alkyl group or the like; B represents either of the following groups: wherein R, R, R, and Reach represent a hydrogen atom, a halogen atom, an alkoxyl group or the like; m represents 1 or 2; and the ring of: represents an aromatic heterocyclic ring.

Cyclic amide derivatives

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Tokyo, Japan

Mitsuru Ooizumi