Eisai Company, Limited

Cancer Institute

Mitsubishi Rayon Company, Limited

Nippon Medical School

Mitsuru Emi

Yusuke Nakamura

Masamitsu Onda

Hisaki Nagai

It is intended to provide a system of predicting the postoperative prognosis in a patient with breast cancer from the viewpoint of gene expression based on the data obtained by genome-wide and comprehensive analysis on gene expression in breast cancer. Expression of human genes is comprehensively analyzed by using a DNA microarray and gene expression functions in various breast cancer conditions are compared, thereby establishing a system of predicting the postoperative prognosis of breast cancer.

Gene relating to estimation of postoperative prognosis for breast cancer

The present invention provide a gene present in a commonly deleted region of a chromosome in breast and ovarian cancers and encoding a novel protein, the protein ('MDC protein') encoded by the gene and a method for the diagnosis of cancer by using an antibody combinable to the protein. A detailed genetic map of human chromosome 17 was constructed to analyze the chromosome in breast and ovarian cancer tissues, and a gene encoding a novel protein was cloned and its structure was determined. As a result of gene analysis using DNA probes derived from the gene, a gene mutation was confirmed in breast cancer tissues. Moreover, a transformant carrying a plasmid containing the gene was grown to obtain the MDC protein. Furthermore, a monoclonal antibody was prepared by using the protein as an antigen.

MDC proteins and DNAs encoding the same

The present invention provides an antibody encoded by a gene which is present in a commonly deleted region of a chromosome in breast and ovarian cancers. A monoclonal antibody was prepared by using the protein as antigen and can be utilized in clinical fields for diagnosing cancer.

Antibodies to MDC proteins

The present invention provide a gene present in a commonly deleted region of a chromosome in breast and ovarian cancers and encoding a novel protein, the protein ('MDC protein') encoded by the gene, a method for the diagnosis of cancer by using an antibody combinable to the protein, and others. A detailed genetic map of human chromosome 17 was constructed to analyze the chromosome in breast and ovarian cancer tissues, and a gene encoding a novel protein was cloned and its structure was determined. As a result of gene analysis using DNA probes derived from the gene, a gene mutation was confirmed in breast cancer tissues. Moreover, a transformant carrying a plasmid containing the gene was grown to obtain the MDC protein. Furthermore, a monoclonal antibody was prepared by using the protein as antigen.

Growing community of inventors

Tokyo, Japan

Mitsuru Emi