Osaka University

Other

Nof Corporation

Terumo Kabushiki Kaisha

Tohoku University

Hoechst Aktiengesellschaft

Daikin Industries, Ltd.

Toray Industries, Inc.

Toyoda Gosei Co., Ltd.

Ntn Corporation

Japan Science and Technology Agency

Sumitomo Bakelite Company Limited

Taiho Pharmaceutical Company Limited

Takeda Pharmaceutical Company Limited

Mitsubishi Paper Mills Limited

Mitsuru Akashi

Michiya Matsusaki

Masanori Baba

Akio Kishida

Akio Hayashi

Makoto Onishi

Hiroshi Kikuchi

Yoshiki Sawa

Tetsushi Taguchi

Yotaro Fujita

Shinji Sakuma

Kazunori Okano

Kenji Adachi

Masaki Egami

Chikateru Nozaki

Kohji Nishida

Mikio Murakami

Atsushi Matsuzawa

Kazuyoshi Kaminaka

Masaaki Nawano

Daijiro Shiino

Akihiro Yamanaka

Haruhiko Itoh

Tatsuo Kaneko

Naoto Kuriyama

Koji Hashimoto

Masaki Kuramitsu

Haruka Nakamura

Dongjian Shi

Ryuzo Hosotani

Kensaku Sonoda

Toshiyuki Kida

Satoshi Hirakawa

Naoaki Sakata

Michiaki Unno

Tomofumi Uto

Toukokuryuu Ai

Takami Akagi

Hiroshi Shimoda

Yoshiya Asano

Gumpei Yoshimatsu

Hiroharu Ajiro

Kai Kan

Tran Thi Hang

Takeshi Sakura

Yoshio Nakahara

Yuji Shirakata

Tomonori Waku

Akira Kubota

Eiichi Kato

Kazuhiro Miyawaki

The present invention is to provide a cell chip and a three-dimensional tissue chip and a production method therefor such that even when a highly viscous cell-containing solution is a material, the highly safe and reproducible cell chip or three-dimensional tissue chip with a desired application volume can be produced within a short time and in a large quantity so as to have a desired cell density and exhibit high cell viability.

Cell chip and three-dimensional tissue chip, and method for producing same

The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the cellular tissue, wherein the cellular tissue comprises a fibroblast, an extracellular matrix, and a vascular endothelial cell and/or a lymphatic endothelial cell each capable of forming a lumen; and a method for producing the artificial peritoneal tissue.

Artificial peritoneal tissue and method for producing same

An artificial tissue containing pancreatic islet cells, fibroblasts and/or cells capable of differentiating, extracellular matrix, and vascular endothelial cells, in which the fibroblasts and/or the cells capable of differentiating, the extracellular matrix, and the vascular endothelial cells constitute a three-dimensional tissue structure in which a vascular network structure has been formed, and in which the three-dimensional tissue structure contains pancreatic islets constituted by aggregating ten or more of the pancreatic islet cells.

Artificial tissue and method for producing same

A polylactide derivative according to the present invention is expressed by the following general formula (1) or general formula (2): In general formula (1), one of X1-X5 is an aldehyde group, one of the other four is an alkoxy group, and the other three are hydrogen atoms. In general formula (2), one of R1-R3 is selected from a chlorine atom, fluorine atom, aldehyde group, alkoxy group, alkyl group and ester, while the other two are selected from the chlorine atom, fluorine atom, aldehyde group, alkoxy group, alkyl group, ester, and hydrogen atom.

Polylactide derivative, method for producing same, and polylactide stereocomplex

Provided is a novel method capable of producing an artificial skin model. A method for producing an artificial skin model includes: providing coated cells (), each of which is obtained by covering the surface of a cell () with a coating film () containing an extracellular matrix component; forming a dermis tissue layer (), in which the coated cells () are laminated, by culturing the coated cells (); and forming an epidermis layer () by arranging epidermis cells () on the dermis tissue layer ().

Method for producing artificial skin model, and artificial skin model

The present invention is to provide a material that is capable of selectively adsorbing organic fluoro-compounds such as perfluorooctane sulfonic acid, allows the adsorbed organic fluoro-compounds to be recovered, and is reusable as an adsorbent, specifically to provide a polymer in which cyclodextrin is supported on the surface of a water-insoluble polymer, and an adsorbent containing the same, and a method of use of the same as a selective adsorbent of, in particular, an organic fluoro-compound.

Adsorbent for organic fluoro-compound comprising cyclodextrin-supported polymer

A polyion complex (PIC) or a PIC nanoparticle that may be easily prepared, and that is finally disappeared in vivo due to its suitable biodegradability while exhibiting high stability in vivo, an immunotherapy agent comprising the PIC nanoparticle to which various antigen proteins or peptides may be easily conjugated or incorporated and/or which may be easily mixed with the antigen proteins or peptides, as well as a process for preparing thereof are provided. Specifically, a polyion complex (PIC) comprising a hydrophobized poly(acidic amino acid) and a basic polypeptide, a nanoparticle thereof having a particle shape, an immunotherapy agent comprising the PIC nanoparticle, as well as a process for preparing the PIC, comprising steps of introducing a hydrophobic amino acid to a poly(acidic amino acid) to prepare a hydrophobized poly(acidic amino acid), and dissolving the hydrophobized poly(acidic amino acid) prepared to a buffer, and it is mixed with a basic polypeptide dissolved in a buffer.

Polyion complex comprising hydrophobized polyamino acid and use of the same

A hydrophilic material having a hydrophilic nature and being biocompatible and processable into nanoparticles wherein a hydrophilic monomer such as threitol or a hydrophilic polymer such as polyethylene glycol is attached to the &#x3b2;position of an &#x3b1;,&#x3b2;-unsaturated carboxyl group of a (co)polymer comprising an aromatic compound such as 4-hydroxycinnamic acid in which an aromatic ring is substituted by the &#x3b1;,&#x3b2;-unsaturated carboxyl group and one or more hydroxyl groups. In particular, a hydrophilic material having a nanoparticle size which is highly dispersible in water, can well migrate into the blood and is useful as a drug carrier, a medical material and a sustained drug release material.

Hydrophilic material, medical material and sustained drug release material

Disclosed is a method for detecting a biological signal of a three-dimensional cell culture construct. The method for detecting a biological signal of a three-dimensional cell culture construct includes: providing a three-dimensional cell culture construct that contains at least two cell layers laminated to each other and a sensor particle capable of detecting a biological signal; and observing the sensor particle optically. Preferably, the three-dimensional cell culture construct contains an extracellular matrix including a combination of a protein or polymer having an RGD sequence and a protein or polymer that interacts with the protein or polymer having the RGD sequence, or a combination of a protein or polymer that is positively charged and a protein or polymer that is negatively charged.

Method and kit for detecting biological signal of three-dimensional cell culture material

The present invention provides a collagen crosslinking agent superior in biocompatibility that is free from the damage by UV irradiation and also from the problems of toxicity caused by residual monomer or unreacted functional groups. Provided is a noncovalent collagen crosslinking agent (for fibrous protein collagen), comprising a spacer of a polyvalent alcohol having two or more OH groups at the terminals and arms of collagen peptides formed of repetitions of three amino acids, the arms being bound via the OH groups to the spacer.

Noncovalent collagen crosslinking agent

To provide a new reductive-stimuli-responsive degradable gel that allows any control of decomposition of the three-dimensional base material for cell culture and production of a completely biological three-dimensional cellular structure consisting only of cells and cells-produced extracellular matrix and that allows safe recovery of the cellular structure produced. A stimuli-responsive hydrogel, characterized by being produced by crosslinking a water-soluble polymer with a compound having a disulfide bond in the molecular chain.

Controllably degradable hydrogel for culturing cells to produce three-dimensionally organized cells

A bioabsorbable material which is flexible and degradable at a controlled rate, and an in-vivo indwelling device made thereof. The bioabsorbable material is a copolymer composed of an aromatic compound having an &#x3b1;,&#x3b2;-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, and a polycarbonate or a monomer constituting polycarbonate. Alternatively, it is a copolymer composed of, as the first component, an aromatic compound having an &#x3b1;,&#x3b2;-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, as the second component, an aromatic compound having an &#x3b1;,&#x3b2;-unsaturated carboxylic group and at least two hydroxyl groups as substituents on the aromatic ring, and, as the third component, a polycarbonate or a monomer constituting polycarbonate.

Bioabsorbable material and in-vivo indwelling device made thereof

The present invention provides a novel method of producing a three-dimensional tissue by which cell lamination can be carried out easily. According to the method, a three-dimensional tissue in which cell layers are laminated with an extracellular matrix intervening between each pair of the adjacent cell layers is produced by: (A) forming a cell layer on a substrate; (B) bringing the cell layer formed on the substrate into contact with a solution containing a first substance and a solution containing a second substance alternately, thus forming, on the cell layer, an extracellular matrix in which the first substance and the second substance are laminated alternately; and (C) culturing a cell on the extracellular matrix to form a further cell layer. In the present invention, a combination of the first substance and the second substance is (a) a combination of a protein or polymer having an RGD sequence and a protein or polymer that interacts with the protein or polymer having the RGD sequence or (b) a combination of a protein or polymer that is positively charged and a protein or polymer that is negatively charged.

Method of producing three-dimensional tissue and method of producing extracellular matrix used in the same

Use of a polyamino acid as an adjuvant; an application of a polyamino acid as an adjuvant in the production of a vaccine; a vaccine comprising a polyamino acid as an adjuvant; a biodegradable nanoparticle having a virus antigen immobilized thereon; and a vaccine comprising the biodegradable nanoparticle.

Polyamino acid for use as adjuvant

Growing community of inventors

Suita, Japan

Mitsuru Akashi