Zeria Pharmaceutical Co., Ltd.

Hisayoshi Kato

Tomoji Aotsuka

Naoki Nakata

Mitsuo Soeda

Kuniyoshi Ogura

Naoyoshi Miura

Hikari Morita

Motoki Torizuka

Yoshiaki Tanaka

Akihiro Okubo

Noaki Nakata

Hikaru Morita

Phenylalkanoylamine derivatives, process for preparing the same, and

Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I), ##STR1## wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R.sup.1 represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R.sup.3 represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Condensed benzene derivative

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Konan, Japan

Mitsuo Soeda