Kyorin Pharmaceutical Co., Ltd.

Mitsuo Ohashi

Katsuya Awano

Toshio Tanaka

Kyuya Okamura

Tetsuya Kimura

Koji Murakami

Michiro Ohnota

Yoshihiro Hirata

Kuniyoshi Masuzawa

Keigo Nishino

Tetsuya Kishi

Norihisa Ishikawa

Phenoxyalkylcarboxylic acid derivative represented by the following formula,wherein Rindicates hydrogen atom, methyl group or ethyl group, m is an integer from 2 to 5, and n is an integer from 3 to 8, Xand Xeach independently represent sulfur atom, oxygen atom, sulfinyl group or sulfonyl group, proviso Xand Xare not simultaneously oxygen atom; their alkali salts and hydrates thereof are useful as antiallergic agents.

Phenoxyalkylcarboxylic acid derivatives and process for their preparations

Thiazolidine-2,4-dione derivatives, their salts and their preparation

Thiazolidine-2,4-dione derivatives, salts and preparation processes

Phenoxyalkylcarboxylic acid derivatives represented by the following formula (I) ##STR1## having a strong and selective leukotriene antagonistic action and useful for prophylaxis and therapy of allergic diseases as asthma and processes of preparing the same.

Phenoxyalkylcarboxylic acid derivatives and process of preparing the same

Phenoxyalkylcarboxylic acid derivatives of the following formula, ##STR1## wherein R.sup.1 indicates a hydrogen atom, a methyl group or an ethyl group, m is equal to 2, 3 or 4, and n is equal to 3 or 4, their alkali salts and hydrates thereof are useful as antiallergic agents.

Phenoxyalkylcarboxylic acid derivatives and process for their preparation

Phenoxyalkylcarboxylic acid derivatives of the following formula, ##STR1## wherein R.sup.1 indicates hydrogen atom, methyl group or ethyl group, m is an integer from 2 to 5, and n is an integer from 3 to 8, X.sup.1 and X.sup.2 each independently represent sulfur atom, oxygen atom, sulfinyl group or sulfonyl group, proviso X.sup.1 and X.sup.2 are not simultaneously oxygen atom; their alkali salts and hydrates thereof are useful as antiallergic agents.

Phenoxyalkylcarboxylic acid derivatives and process for their

Benzimidazole derivatives of the following formula, ##STR1## wherein R.sup.1 indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 6 or dimethylaminopropyl group, R.sup.2 indicates hydrogen atom or lower alkanoyl group having carbon atoms of 1 to 3, R.sup.3 indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or lower alkanoyl group having carbon atoms of 1 to 3, X indicates sulfur atom, sulfinyl group, sulfonyl group, amino group or methylene group, A indicates alkylene group having carbon atoms of 1 to 12, which alkylene group may optionally be substituted by hydroxy group or lower alkyl group having carbon atoms of 1 to 3, --(CHR')N--CR'.dbd.CR'--(CHR')M--, ##STR2## (in which R' and R' are each independently hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or hydroxy group, and n and m are equal to 0, 1, 2 or 3) and Y indicates oxygen atom or sulfur atom; their acid or alkali salts and hydrate thereof are useful as antiallergic agents.

Benzimidazole Derivatives

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Ohmiya, Japan

Mitsuo Ohashi