Other

Eisai R&d Management Co., Ltd.

Hiroshima University

Japan Tissue Engineering Co., Ltd.

Hitachi Metals, Ltd.

Shibaura Institute of Technology

Mitsuo Ochi

Ikada, Yoshito

Ochi, Mitsuo

Toyokazu Kurushima

Masakazu Katoh

Junji Iwasa

Masatoshi Tobita

Takeyuki Yamamoto

Rika Fukushima

Masato Murakami

Masaaki Aoki

Yoshito Ikada

Katsura c/o Rinpia Ooya 402 Sugawara

An internal joint cavity expander includes femur-side magnets, tibia-side magnets, and magnetic shield-members. Each femur-side magnet has a plate curved into an arc and fixed to a femur. Each tibia-side magnet has length smaller than the femur-side magnet length and having a plate curved into arc concentric with the femur-side magnet arc. Each tibia-side magnet is fixed to a tibia. The pole on the convex surface of each femur-side magnet is same as the pole on the concave surface corresponding tibia-side magnet. The convex surface of each femur-side magnet faces the concave surface of corresponding tibia-side magnet. Each magnetic shield-member covers the surface of corresponding femur-side magnet and tibia-side magnet facing the skin throughout range in which the femur-side magnet moves relative to the tibia-side magnet. Each magnetic shield-member prevents magnetism of corresponding magnets and from leaking outside without hindering the femur-side magnet movement relative to the tibia-side magnet.

Internal joint cavity expander

A fixation device set S includes an external fixation device which is attached on one end-side of first and second pins; and a pin fixture which is attached on the other end-side. The external fixation device includes a first and a second permanent magnets disposed with their same poles opposed to each other; a first holding portion provided in the first permanent magnet; a second holding portion provided in the second permanent magnet; first limiter portions sandwiching the first and the second permanent magnets from a second direction; and second limiter portions connecting the first limiter portions to each other. The first pins are inserted through through-holes in the first holding portion, whereas the second holding portion is attached to the second pin via a ball joint.

External fixation device and fixation device set

The invention provides a magnetic induction system and an operating method for it in which the magnetic force can be made to act deeply and widely in any desired direction. The magnetic induction system of the invention contains multiple magnetic field generation means formed of a superconductive bulk magnet, a drive means for arranging the magnetic field generation means at a desired site and angle, and a drive control means for driving the driving means and controlling the position and the angle of the multiple magnetic field generation means so that a magnetic complex can be inducted to the desired position in a body by the synthetic magnetic field formed by the multiple magnetic field generation means, whereby the magnetic complex is inducted to be concentrated in the cartilage defected part.

Magnetic induction system and operating method for same incorporation by reference

In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.

Magnetic cell and method of using the same

To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring device includes a detecting unit and calculation means, the detecting unit includes a contact unit, a vibrator connected to the contact unit, and a vibration detecting unit for detecting the vibration of the vibrator, and the calculation means determines stiffness information by calculation based on the detected result from the vibration detecting element; and by bringing the contact unit into contact with the cultured tissue. With this method the transplant compatibility of the cultured tissue can be nondestructively and easily determined easily and the quality of the cultured tissue can be appropriately controlled.

Method for measuring stiffness of a cultured tissue, using a stiffness measurement device having a vibration detective unit

Methods for measuring stiffness of cultured tissue, for determining transplant compatibility, for quality control, and for preparing transplant-compatible cultured tissue

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Hiroshima, Japan

Mitsuo Ochi