Funai Yakuhin Kogyo Kabushiki Kaisha

Funai Kakuhin Kogyo Kabushiki Kaisha

Mitsuo Nakamura

Setsuro Fujii

Naoki Umeda

Masahiro Kawasaki

Bompei Yasui

Tomohisa Miyamoto

Kazuko Ando

Iwao Hashimoto

Mitsuru Hirohashi

Yoneichi Sawai

New ester derivatives of alkoxybenzoyldeoxyfluorouridine of the general formula ##STR1## wherein R stands for an alkoxy group having 1 to 4 carbon atoms, m for 1 or 2, and n for 3 or 4 with the proviso that when m is 2, the adjacent two R's may be combined to form an alkylenedioxy group as a whole. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, especially for oral administration.

Ester derivatives of alkoxybenzoyldeoxyfluorouridine

New ester derivatives of deoxyfluorouridine of the general formula: ##STR1## wherein R and R.sup.40, may be identical or different, and may be hydrogen, halogen or methyl and n is 3 or 4. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, especially for oral administeration.

Ester derivatives of deoxyfluorouridine

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Kyoto, Japan

Mitsuo Nakamura