Nippon Chemiphar Co., Ltd.

Mitsuko Yoshioka

Mitsuo Masaki

Toru Yamanaka

Kazuki Okai

Terumasa Moriga

Yoshimi Nakamigawa

Yoshiomi Sakamoto

Hiroyasu Uchiyama

Heinojo Yamasaka

Hirotaka Masuda

A stabilized physiologically active benzimidazole derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a fluoroalkyl group having 1 to 6 carbon atoms, a cycloalkyl group, phenyl group or an aralkyl group, R.sup.2 is hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form a ring, and each of R.sup.3a, R.sup.3b, R.sup.4a, R.sup.4b and R.sup.4c independently is hydrogen atom, a halogen atom, a fluoroalkyl group having 1 to 6 carbon atoms, a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or an amino group. The stabilized benzimidazole derivative is in amorphous form or present in contact with a basic material.

Stabilized benzimidazole derivative and composition

An N-acylcarnosine aluminum salt of the formula, ##STR1## wherein R represents a lower alkyl group having 1 to 6 carbon atoms is effective for use as an anti-ulcer agent.

N-Acrylcarnosine aluminum salts

Growing community of inventors

Yoshikawa, Japan

Mitsuko Yoshioka