University of California

Mitsuko L Yamamoto

Jonathan Braun

Robert H Schiestl

Ramune Reliene

James Borneman

Laura L Presley

Inoculation of ATM-deficient mice with probiotic microorganisms, such as, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone disease, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespans in a simple, non-invasive manner.

Compositions and methods for promoting growth of beneficial microbes to treat or prevent disease or prolong life

Inoculation of ATM-deficient mice with probiotic microorganisms, such as, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone diseases, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespan in a simple, non-invasive manner.

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Alameda, CA, United States of America

Mitsuko L Yamamoto